Diet Pills For Diabetes Type 2 – In a study of people who were overweight or obese but did not have type 2 diabetes, the weekly injection helped many lose an average of 50 pounds.
Tirzepatide is part of a new class of drugs that target two hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Courtesy of Eli Lilly and Company; Canva
Diet Pills For Diabetes Type 2
A weekly injectable recently approved to treat type 2 diabetes may have major potential as a weight-loss drug for obese people as well, a study suggests.
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Overweight or obese participants without type 2 diabetes who took the drug, called tirzepatide (sold as the diabetes drug Mounjaro), lost an average of nearly 21 percent of their body weight at the highest dose studied. The scientists presented their findings at the annual meeting of the American Diabetes Association (ADA) in New Orleans and published the study in The New England Journal of Medicine.
“Certainly, the weight loss in this study is much more than we’ve ever seen with other FDA-approved drugs in terms of the absolute amount of weight lost or the percentage of weight lost,” says Osama Hamdy, MD, PhD, associate professor . at Harvard Medical School and medical director of the clinical obesity program at the Joslin Diabetes Center in Boston. Dr. Hamdy was not involved in the new study; received funding from Eli Lilly, the manufacturer of tirzepatide.
The study enrolled 2,539 adults who weighed an average of 231 pounds and had a body mass index (BMI) of 38 to start. A BMI of 30 or higher is considered obese, and 95% had a BMI at least that high.
Participants were randomly assigned to receive 72 weeks of once-weekly injections of placebo or one of three doses of tirzepatide — 5 milligrams (mg), 10 mg, or 15 mg.
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At the highest dose, people lost an average of 20.9 percent of their body weight by the end of the study, or about 52 pounds. Their average weight loss, 19.5 percent, was the equivalent of about 49 pounds with the 10 mg dose and 15 percent, or about 35 pounds, with the 5 mg dose.
Most side effects were mild to moderate and most often involved gastrointestinal problems such as nausea, diarrhea, and constipation; approximately 4 to 7% of participants discontinued treatment due to drug-related side effects.
This was a phase 3 clinical trial, which is usually the final stage of testing to be considered for US regulatory approval.
“These results are an important step forward in expanding the potential for effective therapeutic options for people with obesity,” says lead study author Ania Jastreboff, MD, PhD, associate professor at Yale University School of Medicine and co-director of the Yale Center for Weight Management in New Haven, Conn.
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“Notably, about 9 out of 10 people with obesity lost weight while taking tirzepatide,” says Dr. Jastreboff, who has financial ties to several pharmaceutical companies, including Eli Lilly, the maker of tirzepatide and the funder of the new clinical trial.
Tirzepatide is the first in a new family of drugs that target two hormones – glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) – that are involved in maintaining healthy blood sugar levels and transmitting signals from the gut to the brain when people are full.
The US Food and Drug Administration (FDA) approved tirzepatide in May to help manage blood sugar in people with type 2 diabetes; the diabetes treatment is called Mounjaro.
A head-to-head clinical trial found that tirzepatide in this setting was more effective at controlling blood sugar and promoting weight loss in patients with type 2 diabetes than semaglutide (Ozempic), an injected GLP-1 receptor agonist, or two forms used commonly by insulin, according to the FDA.
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In this earlier study, tirzepatide reduced so-called hemoglobin A1C levels, which reflect average blood sugar levels over about three months, by 0.5% more than semaglutide and about 1% more than insulin, he said FDA.
The 15-mg dose of tirzepatide helped obese type 2 diabetes patients lose 12 pounds more than semaglutide and 27 to 29 pounds more than the two forms of insulin evaluated, the FDA noted.
A drawback of the new study of tirzepatide for obesity is that it did not directly compare this drug with other treatment options. Hamdy says head-to-head trials against semaglutide and another similar drug, liraglutide, will be needed to confirm whether tirzepatide really is the best drug for obesity. Hamdy also received funding from Novo Nordisk, the maker of semaglutide.
The results of the new study suggest that tirzepatide at the highest dose may work as well as bariatric surgery, Hamdy notes. But if tirzepatide wins FDA marketing approval, how much patients use the drug may ultimately come down to price.
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“Obesity is a serious disease that can lead to many costly complications, including diabetes, high blood pressure and cardiovascular disease,” says Hamdy. He doesn’t expect tirzepatide to be cheaper than other new weight-loss drugs, such as semaglutide (Wegovy) or liraglutide (Saxenda), which retail for more than $1,300 a month, according to prices on GoodRx.
Because of all the health risks of obesity and how many patients struggle to lose weight and not keep it off, more treatment options are still needed, says Clifford Rosen, MD, a professor at Tufts University School of Medicine in Boston. and the Mainehealth Institute for Research in Scarborough, Maine, which was not involved in the study and has no financial ties to the companies.
“There is nothing wrong with the other interventions, including current GLP-1R agonists and bariatric surgery,” says Dr. Rosen. “But if tirzepatide produces weight loss similar to bariatric surgery, that would be a huge advance and a great alternative to surgery.”
Eli Lilly did not immediately respond to a request for comment on how soon the company may seek FDA approval for tirzepatide for obesity.
Dietary And Nutritional Approaches For Prevention And Management Of Type 2 Diabetes
What are the possible complications of type 2 diabetes and how can you avoid them? Until March 11, 2023 People living with diabetes have special dietary requirements, but what is often overlooked is the need to supplement their diet with vitamins and minerals.
However, there are certain nutrients that people with diabetes should pay special attention to, making sure they get them regularly. This article will outline which vitamins are recommended for people with diabetes and ways to make sure you are taking them regularly.
It does not mean that people with diabetes do not absorb vitamins well or have problems with digestion (unless you suffer from gastroparesis, which is common in people with diabetes). Vitamins simply help people supplement their diet, especially if they struggle to eat enough fruit and vegetables, and vitamins are essential to living a healthy life if you have a chronic condition like diabetes.
It’s important to always talk to your doctor, who may order blood tests to see if you have vitamin deficiencies. By working with your care team, you can choose the best supplements for you and your lifestyle.
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Those with type 1 or type 2 diabetes are more likely to have lower levels of thiamine in their blood and are usually at greater risk of thiamine deficiency than people who do not have diabetes. This vitamin is helpful in relieving neuropathy pain.
Major sources of thiamine include beef, pork, nuts, whole grains, legumes, cauliflower, oranges, eggs, potatoes, asparagus, and kale.
Vitamin B12 is vital for healthy red blood cells and brain function. People with diabetes who suffer from nerve damage in their hands and feet may see their symptoms worsen if they are deficient in vitamin B12. Studies have shown that long-term use of the diabetes drug Metformin can lead to a vitamin B12 deficiency.
Common sources of this vitamin include fish, milk, eggs and meat products. Vitamin B12 can also be taken orally for vegetarians and vegans.
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Vitamin D deficiencies are linked to the development of diabetes, and a study in Denmark showed that chronically low vitamin D levels in people with diabetes can lead to an increased risk of complications and death.
Many people with diabetes also have low levels of vitamin D, so be sure to supplement your diet with plenty of egg yolks, liver, fish and dairy products with the added nutrient.
Regular sun exposure (between 10-30 minutes a day) can also help you get higher levels of vitamin D.
Magnesium maintains a healthy immune system, strengthens bones, regulates heart rate, and helps the body digest and use the nutrients in the foods we eat every day.
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This essential nutrient is often low in people with type 2 diabetes. Low levels of magnesium have been linked to insulin resistance, while a study published in Diabetes Care found that taking the vitamin regularly can reduce the risk of developing diabetes. type 2.
Magnesium is often taken in supplement form along with calcium and zinc or found in foods such as legumes, rice, beans, nuts, green leafy vegetables and wheat products.
Vitamin E fights external toxins, improves the effectiveness of insulin and oxygenates the blood. Taking a vitamin E supplement can help prevent premature aging and cell damage, decrease the likelihood of developing type 2 diabetes, and help maintain blood sugar levels in people with diabetes.
Many people with diabetes suffer from low levels of vitamin C. Increasing one’s intake
