Online Weight Loss Clinic Phentermine – Managing your weight is key to quality of life, and it’s important to do so in a safe and healthy way. Our GPs can provide medical care and support to help with your weight loss and management goals.
If you are working to lose weight or need support to keep it off, or if you would like advice before starting a weight loss programme, our GPs can help guide you.
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Get medical advice, prescriptions and ongoing support from a licensed physician in the privacy and comfort of your own home.
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Doctors may prescribe weight loss medications, appetite suppressants, and obesity treatments to help patients manage their weight. Consult a doctor conveniently online through the DA app for reliable weight management advice and support.
A prescription injectable drug that is an appetite suppressant. For adults and children aged 12 years and older who may have problems with obesity.
An enzyme blocker that reduces the absorption of some of the fats in food. For adults with BMI ≥30 with associated risk factors, e.g. hypertension, diabetes.
A GP will ask questions to understand your diet and lifestyle and provide advice and support to help you achieve long-term weight loss. To complement sensible eating and lifestyle habits, your GP may prescribe medications such as appetite suppressants or enzyme blockers to increase the effectiveness of your weight loss or management plan.
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The doctor will assess your health condition based on your age, medical history and lifestyle factors etc. to recommend a program that is best suited to achieve your goals. Since there can be mild side effects of weight loss medications, do not start a program before discussing it with your doctor.
Using prescription weight loss medications to support healthy lifestyle habits can help you reach your weight loss goals faster than exercise and diet alone. This may encourage patients to stick with the program for better long-term results.
The FDA has approved several medications for the treatment of obesity in children and adolescents. Talk to your doctor to understand your options and discuss your treatment plan.
Our doctors on the Doctor Anywhere platform can consult on weight loss and management issues and prescribe weight loss medications if your condition is deemed suitable. Medicines are delivered to your doorstep within 3 hours. Download the Doctor Anywhere app and connect with a licensed physician in minutes to discuss your concerns. Phentermine is an oral sympathomimetic amine used as an adjunct to the short-term (eg, 8-12 weeks) treatment of exogenous obesity. The pharmacological effects of phentermine are similar to amphetamines. Phentermine resin compound was approved by the FDA in 1959, but is no longer marketed in the US. Phentermine hydrochloride was approved by the FDA in 1973. In the mid-1990s, there was renewed interest in phentermine in combination with another anorectic, fenfluramine, for the treatment of obesity and substance abuse, however, little scientific data supported it this practice. On July 8, 1997, the FDA issued a ‘Dear Health Care Professional’ letter warning physicians about the development of valvular heart disease and pulmonary hypertension in women taking the combination of fenfluramine and phentermine; fenfluramine was subsequently withdrawn from the US market in the fall of 1997. The use of phentermine with other anorectic agents for obesity has not been evaluated and is not recommended. In May 2011, the FDA approved an orally disintegrating tablet of phentermine hydrochloride (Suprenza) for the treatment of exogenous obesity.1
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Limited data are available in reference texts regarding the mechanism of action of this drug. Phentermine is an analog of methamphetamine. Similar to amphetamines, phentermine increases the release of norepinephrine and dopamine from nerve terminals and inhibits their reuptake. Thus, phentermine is classified as an indirect sympathomimetic.2 Other effects include a weak ability to dose-dependently increase serotonin levels, although the effect on serotonin is less potent than that of methamphetamine itself.3 Clinical effects include stimulation of CNS and blood elevation. the pressure. Appetite suppression is believed to occur through direct stimulation of the satiety center in the hypothalamic and limbic regions.
Tolerance to the anorexic effects of phentermine usually develops within a few weeks of starting therapy. The mechanism of tolerance appears to be pharmacodynamic in nature; higher doses of phentermine are needed to produce the same response. When tolerance to the anorexic effects develops, it is generally recommended to discontinue phentermine rather than increase the dose.
Phentermine is administered orally. The rate and extent of exposure of phentermine under fasting conditions is equivalent regardless of the oral formulation administered.1
There are limited data on the pharmacokinetics of phentermine. Phentermine is mainly excreted by the kidneys. The elimination half-life ranges from 19-24 hours and is influenced by urinary pH. Because the pKa of phentermine is 9.84, the elimination half-life is reduced to about 7-8 hours under acidic urinary conditions.
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Oral Route: After oral administration, the greatest absorption of phentermine occurs from the small intestine. The duration of action after administration of 8 mg capsules or tablets is about 4 hours and 12-14 hours after administration of 30 mg capsules or 37.5 mg tablets.
Phentermine orally disintegrating tablet (ODT) reaches maximum concentrations (Cmax) 3-4.4 hours after administration. Swallowing water before swallowing ODT did not affect AUC. Despite a decrease in Cmax (approximately 5%) and AUC (approximately 12%) when phentermine ODT was administered after a high fat/calorie breakfast, phentermine ODT can be administered with or without food. Cmax and AUC decreased by approximately 7% and 8%, respectively, when ODT was ingested without prior dissolution.1
Renal impairment: Use with caution in patients with renal impairment. Cumulative urinary excretion of phentermine under uncontrolled urinary pH conditions is 62-85%, and increased exposure can be expected in patients with renal impairment.1
According to the manufacture of phentermine capsules and tablets, its products are contraindicated in patients with cardiac disease, advanced arteriosclerosis, moderate to severe hypertension, agitated state or glaucoma. diseases including coronary artery disease, stroke, cardiac arrhythmias, heart failure, and uncontrolled hypertension.5 Valvular heart disease has been reported in women taking the combination of fenfluramine and phentermine; the safety and efficacy of combination therapy with phentermine and any other weight loss medication, including selective serotonin reuptake inhibitors (eg, fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. Therefore, co-administration of these medicinal products for weight loss is not recommended. Furthermore, primary pulmonary hypertension (PPH) has been reported to occur in patients receiving a combination of phentermine with fenfluramine or dexfenfluramine. The possibility of an association between phentermine use alone and PPH or valvular heart disease cannot be excluded. The initial symptom of PPH is usually dyspnea. Other initial symptoms include: angina pectoris, syncope or edema of the lower extremities. Patients should be advised to promptly report any deterioration in exercise tolerance. Treatment should be discontinued in patients who develop new, unexplained symptoms of dyspnoea, angina pectoris, syncope, or edema of the lower extremities.
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Because phentermine is a sympathomimetic agent, it is contraindicated in patients with hyperthyroidism. It should also be used with caution in patients with thyroid disease.
Phentermine is contraindicated for use during or within 14 days of the use of MAOI therapy or other drugs with MAO inhibitory activity. Monoamine oxidase (MAO) inhibitors, or drugs that have MAO inhibitory activity, such as furazolidone or procarbazine, may prolong and intensify the cardiac stimulation and vasopressor effects of phentermine.
Phentermine is contraindicated in patients with anxiety. worsen these effects or cause an adverse drug reaction.4 Symptoms of chronic intoxication include insomnia, irritability, personality changes, and psychotic symptoms that may be clinically indistinguishable from other psychotic disorders, such as schizophrenia. Phentermine may worsen certain mental conditions, such as those patients who exhibit very nervous or agitated behavior, including psychosis, mania, or severe anxiety.
Use of phentermine may cause dizziness, mask signs of fatigue or the need for rest, or impair the patient’s ability to participate in activities that require mental alertness. Advise patients to use caution when driving or operating machinery, or when performing other tasks that require mental alertness until they are aware of how the therapy will affect their mental and/or motor performance. In general, ingestion of ethanol may exacerbate these effects or cause an adverse drug reaction.4 Advise patients to avoid alcohol while taking phentermine.
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Use phentermine with caution in patients with diabetes mellitus. The requirements for insulin or other antidiabetic drugs may be altered in these patients when using phentermine during weight loss and due to the altered dietary regimen. Patients should monitor their blood glucose regularly and follow their healthcare provider’s recommendations. 5
Appetite suppression therapy is not recommended for use in those patients with a history of anorexia nervosa or other eating disorders. The use of phentermine is contraindicated in patients with a known history of drug or substance abuse. Phentermine is chemically and pharmacologically related to the widely abused amphetamines. The potential for phentermine abuse should be kept in mind when evaluating the desirability of including the drug as part of a weight loss program. The smallest reasonable amount should be prescribed or dispensed at one time in order to limit the potential for overuse or diversion of the drug.5
Phentermine products are now classified as a pregnancy hazard by the FDA
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