Phentermine 37.5 Weight Loss Pills – Phentermine is a medicine used together with diet and exercise to help with weight loss in people who are overweight or obese.
Do not use phentermine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction may occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
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Losing weight during pregnancy can harm your unborn baby, even if you’re overweight. Do not use phentermine if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
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Get emergency medical help if you have signs of an allergic reaction: hives; shortness of breath; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and other possible side effects. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.
Avoid driving or dangerous activities until you know how this medicine will affect you. Your reaction may be impaired.
Use Phentermine (Lomair) exactly as directed on the label or as directed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
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Follow all directions on your medication label and read all medication instructions or instruction sheets. Your doctor may sometimes change your dosage. Use the medicine exactly as directed.
Phentermine is usually taken before breakfast, or 1 to 2 hours after breakfast. Follow your doctor’s medication instructions very carefully.
Never use phentermine in larger amounts or for longer than prescribed. Taking too much of this medicine will not make it more effective and can cause serious, life-threatening side effects.
Phentermine is for short-term use only. The appetite suppressant effect may disappear after a few weeks.
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Phentermine can be habit-forming. Abuse can cause addiction, overdose, or death. Selling or giving away this drug is against the law.
Call your doctor right away if you think this medicine is not working as well or if you have not lost at least 4 pounds within 4 weeks.
Do not stop using phentermine suddenly, or you may have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat. Hold the bottle tightly when not in use.
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Take the medicine as soon as possible, but skip the missed dose if it is late in the day. Do not take two doses at the same time.
Overdose symptoms may include confusion, panic attacks, hallucinations, extreme restlessness, nausea, vomiting, diarrhea, stomach cramps, feeling tired or depressed, irregular heartbeat, pulse weakness, convulsions, or slow breathing (may stop breathing).
If you think you or someone else may have overdosed on: Phentermine (Lomaira), call your doctor or a poison control center
This medication should be taken as part of a weight loss plan that includes diet and exercise.
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Phentermine should only be used by people who cannot lose enough weight with diet and exercise alone; It is not recommended for people who just want to lose a few pounds.
Drugs from A-Z offers drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides data in several sections Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose and Imaging. Information in all other sections is exclusive to Daily Wellness. Phentermine is an oral sympathomimetic amine used as an adjunct in the short-term (eg, 8-12 weeks) treatment of exogenous obesity. The pharmacological effects of phentermine are similar to those of amphetamines. The phentermine resin complex was approved by the FDA in 1959, but is no longer marketed in the United States. Phentermine hydrochloride was approved by the FDA in 1973. In the mid-1990s, phentermine in combination with another anesthetic, fenfluramine, gained renewed interest in the treatment of obesity and substance abuse, however. , there is little scientific data to support this approach. On July 8, 1997, the FDA issued a letter ‘Dear Health Care Professionals’ warning physicians of the development of valvular heart disease and pulmonary hypertension in women taking the combination fenfluramine and phentermine; fenfluramine was subsequently withdrawn from the US market in the fall of 1997. The use of phentermine with other anesthetics for obesity has not been evaluated and is not recommended. In May 2011, the FDA approved an orally disintegrating tablet of phentermine hydrochloride (Suprenza) for the treatment of exogenous obesity.1
Limited data are available in the literature regarding the mechanism of action of this drug. Phentermine is an analogue of methamphetamine. Similar to amphetamines, phentermine increases the release of norepinephrine and dopamine from nerve endings and inhibits their reuptake. Therefore, phentermine is classified as an indirect sympathomimetic.2 Other effects include a weak ability to increase serotonin levels in a dose-dependent manner, although the effect on serotonin occurs less strongly than that of serotonin. methamphetamine itself.3 Clinical effects include CNS stimulation and hypertension. Appetite suppression is thought to occur through direct stimulation of satiety centers in the hypothalamus and limbic regions.
Tolerance to the anorexia effects of phentermine usually develops within a few weeks of initiating treatment. The mechanism of tolerance appears to be pharmacodynamic in nature; Higher doses of phentermine are required to produce the same response. When tolerability develops into an anorexia effect, it is generally advisable to discontinue phentermine rather than increase the dose.
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Phentermine is taken orally. The rates and extent of exposure to phentermine under fasting conditions were comparable regardless of the oral formulation used.1
Limited data are available on the pharmacokinetics of phentermine. Phentermine is mainly excreted by the kidneys. The half-life is between 19–24 hours and is influenced by urine pH. Because the pKa of phentermine is 9.84, the half-life is reduced to about 7-8 hours under acidic urine conditions.
Oral: Following oral administration, most absorption of phentermine occurs from the small intestine. The duration of action after taking an 8 mg capsule or tablet is approximately 4 hours and 12-14 hours after taking a 30 mg capsule or 37.5 mg tablet.
Phentermine orally disintegrating tablets (ODT) reached peak concentrations (Cmax) 3–4.4 hours after administration. Drinking water before swallowing ODT did not affect the AUC. Despite reductions in Cmax (approximately 5%) and AUC (approximately 12%) when phentermine ODT is administered after a high-fat/high-calorie breakfast, phentermine ODT may be administered with or without food. Cmax and AUC decreased by about 7% and 8%, respectively, when ODT was swallowed without prior degradation.1
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Renal impairment: Use with caution in patients with renal impairment. Cumulative urinary excretion of phentermine under uncontrolled urinary pH is 62–85%, and exposure may be increased in patients with renal impairment.1
According to the manufacturers of phentermine capsules and tablets, its products are contraindicated in patients with heart disease, advanced arteriosclerosis, moderate to severe hypertension, agitated states, or disease increased intraocular pressure. disease including coronary artery disease, stroke, arrhythmia, heart failure, and uncontrolled hypertension.5 Heart valve disease has been reported in women taking a combination of fenfluramine and phentermine; safety and efficacy of combination therapy with phentermine and any other medicinal product for weight loss, including selective serotonin reuptake inhibitors (eg, fluoxetine, sertraline, fluvoxamine, paroxetine) , has not been set. Therefore, these medicinal products should not be used concurrently for weight loss. Furthermore, primary pulmonary hypertension (PPH) has been reported to occur in patients receiving the combination of phentermine with fenfluramine or dexfenfluramine. The possibility of an association between phentermine use alone and PPH or valvular heart disease cannot be excluded. The initial symptom of PPH is usually shortness of breath. Other early symptoms include: angina, syncope, or lower extremity edema. Patients should be advised to report any deterioration in exercise tolerance immediately. Treatment should be discontinued in patients who develop new, unexplained dyspnea, angina, syncope, or lower extremity edema.
Because phentermine is a sympathomimetic, it is contraindicated in patients with hyperthyroidism. It should also be used with caution in patients with thyroid disease.
Use of phentermine is contraindicated during or within 14 days of MAOI therapy or other drugs with MAO inhibitory activity. Monoamine oxidase inhibitors (MAOIs), or drugs with MAO inhibitory activity such as furazolidone or procarbazine, may prolong and enhance the cardiostimulatory and vasoactive effects of phentermine.4
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Phentermine is contraindicated in patients with agitation. Exacerbating these effects or causing adverse drug reactions.4 Symptoms of chronic intoxication include insomnia, irritability, personality changes, and psychotic symptoms that may be indistinguishable. clinically relevant with other psychiatric disorders, such as schizophrenia. Phentermine may aggravate certain psychiatric conditions, such as in patients with anxious or agitated behavior, including psychosis, mania or severe anxiety.
The use of phentermine may cause dizziness, mask signs of fatigue or the need for rest, or impair the patient’s ability to participate in activities that require alertness. Advise patients to exercise caution when driving or operating machinery, or performing other tasks requiring mental alertness until they become aware that therapy will affect mental functioning and/ or how they move. In general, taking ethanol may worsen these effects or cause adverse drug reactions.4 Advise patients to avoid alcohol while taking phentermine.
Use phentermine with caution in patients with diabetes.
