Weight Loss Tablets Doctors Prescribe – Are you trying to lose weight? Metformin can do more than improve blood sugar control—it can help you lose stubborn pounds. Here’s what you need to know about metformin and weight loss.
Although metformin can cause weight loss, a healthy diet and regular exercise are still important if you want to keep the weight off.Darren Lehane/Alamy
Weight Loss Tablets Doctors Prescribe
If you manage type 2 diabetes with Glucophage (metformin), you may be aware of the unwanted side effects of this drug—namely, stomach upset, diarrhea, muscle aches, and drowsiness. These can be symbolic and real pain, but you can accept one side effect of metformin with open arms, especially if you are struggling to lose weight.
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Metformin was not designed to be a weight loss drug, but researchers have found a link between the drug and weight loss. Previous research has concluded that the drug may be effective as a treatment for obesity, although more studies are needed.
Metformin is a common type 2 diabetes drug that the US Food and Drug Administration (FDA) has approved to treat high blood sugar, or hyperglycemia, in people with type 2 diabetes.
“[Metformin] is considered the first-line drug in the treatment of type 2 diabetes, and it primarily works by reducing the amount of glucose produced by the liver,” says Minisha Sood, MD, a board-certified endocrinologist in New York. The city. “It also helps a hormone called insulin to work better by helping the muscles use sugar more efficiently. When insulin works better—and insulin sensitivity improves—a person’s insulin levels are lower than they would otherwise be.
There is no cure for type 2 diabetes, but the right combination of medications and a healthy lifestyle can stabilize blood sugar levels, according to the Mayo Clinic, and in some cases even put type 2 diabetes into remission, according to a study published in Nutrients in April 2019. This, of course, is the ultimate goal of any diabetes treatment.
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As the medicine helps your body reduce blood sugar levels and restore your ability to respond to insulin, you will not only feel better, but you can reduce the risk of future complications of blood sugar, such as heart disease, kidney damage. , nerve damage or diabetic neuropathy, and eye damage (clinically called retinopathy), notes the Cleveland Clinic.
For example, metformin can affect hunger. In a small study, 12 women with obesity and type 2 diabetes who did not take insulin were randomly assigned two levels of metformin – 850 milligrams (mg) or 1,700 mg – or a placebo. three times a day for three days, and each Participant going through the study three times to have each dose and placebo. Participants received a food test every third day and rated their level of hunger before eating. The researchers found that hunger levels in the metformin group were significantly lower, especially with a dose of 1,700 mg compared to a lower dose of metformin or placebo.
Another study, published in May 2020 in the journal Diabetes Care, found that when participants increased their metformin dose by 1,000 mg or more, they lost more weight than those who did not change their metformin dose or reduce their dose . A growing body of research published in journals including Current Obesity Reports suggests that metformin can lead to weight loss due to changes in the brain’s interest centers, changes in the gut microbiome, and alterations in metabolic changes that typically occur with aging.
So it is possible that the side effects of the drug can affect your diet. “Some people taking metformin may experience gastrointestinal side effects such as nausea and diarrhea,” said Rahaf Al Bochi, RDN, a Baltimore-based media spokesperson for the Academy of Nutrition and Dietetics and owner of Olive Tree Nutrition.
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According to a study published in the April–June 2017 Journal of Research in Pharmacy Practice, gastrointestinal side effects are the main complaint among those receiving metformin tablets in their original formulation. The most common symptoms are vomiting, diarrhea, and nausea, which affect anywhere from 2 to 63 percent of people on the drug. The discomfort can be so severe that you may feel like eating too much and then eat fewer calories. Extended-release forms of metformin have few documented side effects, according to previous studies.
Although metformin can lead to some weight loss, the amount you lose may be much less than expected. On average, weight loss after one year on the drug is only six pounds, according to previous research.
So while metformin is often prescribed to people with high insulin levels who have difficulty losing weight, it is not a miracle weight loss solution, says Dr. Sood. In other words, don’t expect big weight changes if you eat too much and lead a sedentary lifestyle. You must follow a sensible weight loss plan with healthy eating and physical activity to see any significant weight change.
“If a person does not follow healthy habits, taking metformin will not lead to weight loss,” he said. “It is important to follow a healthy diet low in refined sugar and carbohydrates if [you] tend to have high insulin levels in order to get maximum benefit from the medicine.”
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Keep in mind that while the number on the scale may decrease while taking this medication, this weight loss may be temporary. You can regain the pounds once you stop taking the drug and your appetite returns to normal – hence the importance of a healthy lifestyle.
And one study, published in May 2019 in the Annals of Internal Medicine, found that people on a diabetes prevention program who lost at least 5 percent of their body weight after a year were more likely to maintain the weight loss longer if they were in the metformin group than if they were assigned to placebo or lifestyle intervention.
What if you don’t have type 2 diabetes? Can you take metformin for weight loss? This is an excellent question, and the short answer is yes.
Sood points out that metformin is used off-label, or off-label as approved by the FDA, for weight management in people without type 2 diabetes.
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Some evidence shows that metformin can be useful for these people: A 2018 study that tested the effectiveness of metformin in weight loss in people who were overweight and obese without diabetes concluded that the drug significantly reduced the body mass index (BMI) in teenagers and adults.
But remember that this drug is only available by prescription and is not approved by the FDA for people who do not have type 2 diabetes. Your doctor will first recommend some of these traditional weight loss strategies:
If you do not have type 2 diabetes, your doctor may prescribe this medication if you are overweight and trying to lose weight. But again, metformin does not replace a healthy diet and regular exercise, which are the keys to sustainable weight loss. These habits also encourage weight loss if you have type 2 diabetes but cannot take metformin.
“Some people cannot tolerate metformin, so it is important to discuss the options you choose with your healthcare provider – medication is one tool to help control blood sugar, but diet and lifestyle changes should be discussed first, because they can significantly reduce blood sugar,” said Al. Bochi.
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What diet and lifestyle changes should you consider? “Dietary changes can include being mindful of your carbohydrate intake, eating enough protein and fat in your diet, choosing high-fiber foods, and reducing your intake of sugary drinks,” said Al Bochi. She also recommends consulting with a registered dietitian about customized nutritional recommendations. “Incorporating some form of movement, such as walking, weight training, or yoga on several days is also important to control blood sugar,” Al Bochi added.
All things considered, in some people with and without diabetes, metformin can cause weight loss. However, scientists are still learning why the drug works. Many factors – including reduced appetite due to the side effects of the drug – are likely to be at play.
Finally, metformin is not a silver bullet. The most important thing you can do to lose weight, whether you’re managing type 2 diabetes or another goal, is to make changes to your diet and lifestyle. Think of metformin as a sidekick in these steps.
Also remember that the FDA has now approved metformin only for certain people with type 2 diabetes, not those without the medical condition. If you are taking blood sugar lowering medication for diabetes, remember that metformin comes with side effects that you will want to discuss and manage with your healthcare team.
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